| abstract |
The present invention relates to a method of preventing or treating hemorrhagic shock (HS), or ameliorating symptoms associated with HS in an individual, by administering an effective amount of a linear, non-cyclic peptide comprising 17 to 21 amino acids, wherein the amino acids in positions (1) to (21) of the peptide, counted from the N-terminus, are as follows: (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K, R or lacking; (10) W, L or F; (11) K or R; (12) F, Y or C; (13) K or R; (14) G or Q; (15) K or R; (16) F, L or W; (17) F or W; (18) F, L or W; (19) W or F; (20) C or lacking; (21) G or lacking, wherein when position (9) is lacking, positions (1) and (21) cannot be lacking. |