| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb351a5a4e03ee3773bd0df5dbae9ac3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-498
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate |
2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dff19a29ca1a4ff8603a808b5a269b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a3119d465b99e9cc57d512d8a0f4870
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d72821b0fca6a2f8d2f5f62d2767bf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59dcc6382a8e904f8ad1a0bbecdadba8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae5b42164d8365c6e5f9fdec1f03ba72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4972dd45232e5d31725605126317a3d0 |
| publicationDate |
2019-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019077769-A1 |
| titleOfInvention |
Compound for Enhancing the Coupling Degree of Complex TRPV4- KCa2.3 and Anti-hypertension Applications thereof |
| abstract |
The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension applications thereof. By finding the structural domains of the interacting sites of the endothelial cell ion channel complex TRPV4-KCa2.3, a compound with specificity which can act at the two interacting sites is prepared in the present invention. It is found that the compound can enhance the space coupling degree of the TRPV4-KCa2.3 complex and has great significance for the research and development of anti-hypertension drugs. |
| priorityDate |
2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |