http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019076653-A1

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publicationDate 2019-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2019076653-A1
titleOfInvention Electrical substance clearance from the brain
abstract A method is provided that includes implanting (a) a parenchymal electrode in or in contact with an outer surface of brain parenchyma of a subject identified as at risk of or suffering from a disease, and (b) a cerebrospinal fluid (CSF) electrode in a CSF-filled space of a brain of the subject, the CSF-filled space selected from the group consisting of: a ventricular system and a subarachnoid space. A midplane treatment electrode is disposed in or over a superior sagittal sinus. Control circuitry is activated to drive the parenchymal electrode and the CSF electrode to drive a substance from the brain parenchyma into the CSF-filled space of the brain, and apply a treatment current between the CSF electrode and the midplane treatment electrode to drive the substance from the CSF-filled space of the brain to the superior sagittal sinus. Other embodiments are also described.
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