| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ee0da6543d4d16f0634e75baf2d0d58 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2521-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1346 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3847
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3895
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0654
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5026 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate |
2018-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f681b836d405bb729c635c966d0ac98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90cc3abf43630820aa8f60f483db1594 |
| publicationDate |
2019-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019054210-A1 |
| titleOfInvention |
Producing bone tissue engineered constructs |
| abstract |
A process for producing a bone construct, including the steps of providing a perfusion bioreactor having an inlet and an outlet; providing the perfusion bioreactor with a seeded scaffold comprising a porous scaffold seeded with mesenchymal stem cells; continuously perfusing the seeded scaffold with an osteogenic induction (differentiation) media; measuring dissolved oxygen content of the osteogenic induction media at the inlet and at the outlet to determine an oxygen uptake rate (OUR) for the seeded scaffold; measuring glucose content of the osteogenic induction media to determine a glucose consumption rate (GCR) for the seeded scaffold; and removing the seeded scaffold from the perfusion reactor as a bone construct after the ratio of the OUR to the GCR (OUR/GCR) has been determined to exceed a predetermined threshold OUR/GCR value. |
| priorityDate |
2017-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |