| abstract |
A method of collecting and sensing a biofluid with enhanced concentration of analytes due to electroporation comprises electroporating biofluid glands ( 14 ) that are generating a biofluid and specifically sensing at least one analyte in said biofluid, the at least one analyte having a molecular weight greater than 50 Da. A device ( 100 ) wearable on a user's skin ( 12 ) for receiving an advective flow of a biofluid comprises at least one of a biofluid stimulation component ( 140 ), a biofluid sensor ( 220, 222 ) specific to an analyte, or a biofluid collection element ( 230, 232 ), at least one electroporation electrode ( 290 ) for enhancing concentration of at least one analyte in the biofluid having a molecular weight of greater than 50 Da, a counter electrode ( 195 ), and an electroporation waveform generator configured to cause the electroporation electrode ( 290 ) to generate and direct a plurality of electroporation pulses into the skin ( 12 ). |