http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019008440-A1

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filingDate 2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_636f5cece1b129539017a1137642f75a
publicationDate 2019-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2019008440-A1
titleOfInvention Method and device to investigate or treat painful neuropathy
abstract A process and laser system for in vitro and in vivo pain research, pain clinical testing and pain management. In preferred embodiments of the present invention a diode laser operating at a 980 nm wavelength is used to produce warmth, tickling, itching, touch, burning, hot pain or pin-prick pain. The device and methods can be used for stimulation of a single nerve fiber, groups of nerve fibers, nerve fibers of single type only as well as more the one type of nerve fibers simultaneously. The device and the methods can be applied in a wide variety of situations involving the study and treatment of pain. Preferred embodiments of the present invention provide laser systems and techniques that permit mapping and selective activation of silent, C-mechano-insensitive fibers or A-delta or C-polymodal fibers, de-functionalization (depleting) of these fibers for the purpose of the treatment of peripheral neuropathy and monitoring of CGRP and substance P associated with stimulation of silent, C-mechano-insensitive fibers.
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