| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_722dfed8b14fa04027be19102c65b8ae |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B63-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate |
2016-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e480a297ccf91fb348fcb6f9c50fe2f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85e0232dd3b1c3c564d0f80b6be66b53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_327b59fa49193630a81988673f7547d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d8b5ee36acdab91bbb901ef8a5c8088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2ba4389238ca576cd3e5e10ad1c315f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_039afb0633fb4469be3f7936142351fa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1718287a71c7ab5cb730be779dfea864 |
| publicationDate |
2019-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019002405-A1 |
| titleOfInvention |
Preparation of latanoprostene bunod of desired, pre-defined quality by gravity chromatography |
| abstract |
The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography. |
| priorityDate |
2015-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |