http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019001018-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b629566dbfda51833001b46b9c7c06f3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1279 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-00951 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-0065 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-785 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-787 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-0036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L26-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L26-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L26-0085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-0031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L26-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L26-00 |
| filingDate | 2018-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08683a95d9e8abaff2288f5017725f77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a0fe881c1ded356a4ab45e70c23801e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_288fac72111561045f076eec993d4894 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03b8dea5a45f9919db32d8d47628cd4e |
| publicationDate | 2019-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2019001018-A1 |
| titleOfInvention | Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices |
| abstract | One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneimine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing photopolymerizable groups with ultraviolet or visible light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneimine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739166-B2 |
| priorityDate | 2006-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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