| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1a6b5ec8904fdec1b3e9cd2181638d7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-35 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-825 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-035 |
| filingDate |
2018-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ebe8ba4fb7afc3f0b3694b2516c5298
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1459c239fc21889a97b10b7ea8f6dbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_070a7dd0e9770faccd312080e88d4bd8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06cf9ceebc139b8b466003e12960e196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ee1b735716a5e664fc2f3fa2d3f6b50 |
| publicationDate |
2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018371061-A1 |
| titleOfInvention |
Application of zn7mt3 and its derivatives in the prevention and treatment of alzheimer's disease |
| abstract |
The present disclosure provides a use based on Zn 7 MT3 or a derivative thereof. Zn 7 MT3 or a derivative thereof is used for prevention or treatment of Alzheimer's disease or other neurodegenerative diseases, or for development, screening or preparation of a medicament suitable for Alzheimer's disease or other neurodegenerative diseases. Further provided are a method for preparing Zn 7 MT3 and a method for preparing gH625-Zn 7 MT3. Zn 7 MT3 and the derivatives thereof of the present disclosure can be used for improving cognitive dysfunction of an AD brain, regulating the cellular morphology of hippocampus in the AD brain, inhibiting the deposition of the amyloid protein in the AD brain and inhibiting the apoptosis of nerve cells in the brain, and can effectively prevent the progression of senile dementia; and the method for preparing Zn 7 MT3 is simple and efficient, and gH625-Zn 7 MT3 can easily cross the blood-brain barrier. |
| priorityDate |
2016-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |