http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018362433-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9882ffc56f5c1db9c0c86477a29da6cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a398ba0ae54daf4d8f1de7e83ca6e1d6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-255 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-022 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-255 |
| filingDate | 2018-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_133572bea1f8165af881f0652b8ed282 |
| publicationDate | 2018-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018362433-A1 |
| titleOfInvention | Novel curcuminoid-inspired synthetic compounds as anti-tumor agents |
| abstract | Novel CUR- and CUR-BF2 compounds exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the α-carbonyl moiety as well as CUR-BF2 adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF3, OCF3, and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR-BF2 compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF3, CF3, and SCF3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The compounds and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines. Deuterated CUR-BF2 and CUR compounds were also synthesized. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022214995-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113289020-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-202100008504-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113845460-A |
| priorityDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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