| abstract |
The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, Cl, F or Br, R 2 is H or F; R 3 is selected from H and alkyl; R 4 is selected from H and C(O)R 6 ; R 5 is H or R 4 and R 5 are linked to form a heterocyclic group which is optionally substituted with one or more R 10 groups R 6 is selected from R 7 , OR 7 and NR 8 R 6 ; R 7 R 8 and R 9 are each independently selected from alkyl, cycloalkyl, aralkyl, cycloalkenyl, heterocycyl and aryl, each of which is optionally substituted with one or more R 10 groups; each R 10 is independently selected from halogen. OH, CN NO 2 , COO-alkyl, aralkyl, SO 2 -alkyl, SO 2 -aryl, COOH, CO-alkyl, CO-aryl, NH 2 , NH-alkyl, N(alkyl) 2 , CF 3 , alkyl and alkoxy, X and Z are each independently CR 11 and Y is selected from CR 11 and N and R 11 is H or F; for use in treating a disorder associated with protein misfolding stress and in particular associated with accumulation of misfolded proteins. |