| abstract |
The present invention provides iRNA agents comprising at least one subunit of the formula (I): n n n n n n n n n n n n wherein: n A and B are each independently for each occurrence O, N(R N ) or S; n X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula (I), —P(Z′)(Z″)— or -Linker-R; n R is L G , -Linker-L G , or has the structure shown below: n n n n n n n n n n n n n n n n L G is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide; n R N is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl; and n Z′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S. |