| abstract |
Applicant provides formulations and pharmaceutical compositions containing glucocorticoid receptor modulators (GRMs) and suitable for treating diseases including Cushing's syndrome, prostate cancer, breast cancer, and other cancers, liver diseases, depression, dementia, stress disorders, and substance abuse disorders. The GRM may be a non-steroidal GRM, and may be an octahydro azadecalin GRM. In particular, the GRM may be CORT125281, which is: ((4aR,8aS)-1-(4-fluorophenyl)-6-((2-methyl-2H-1,2,3-triazol-4-yl)sulfonyl)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone. Methods of treating diseases including Cushing's syndrome, liver diseases, cancers, and psychiatric disorders by administration of a GRM in such pharmaceutical compositions are also provided. |