| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e67739af533921705c6fdeb7b3b25efe |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-24132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-916 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-763
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-763
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2016-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f8fc78c7a3f5e6f071085f39ece0a4b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0765e752c8809be3f5b1fabcd42db56b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_532cf3e1357c39d838f1d00d903a28ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e13fc4894c23099d51607f366f92d983
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57e6526c6715900241498103600f42bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e5b46aa78b3b4b26e1dfb3f74b9d889
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a8b2f6fbbac88998640bb441d9eb364
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49e4f4d69de35dbda9ab4457365efb58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b9b340c47f4b5f6bab201ebcc7de5c9 |
| publicationDate |
2018-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018313843-A1 |
| titleOfInvention |
Samhd1 modulation for treating resistance to cancer therapy |
| abstract |
The present invention pertains to novel treatments for cancer diseases. Treatment of cancers with nucleoside analogs (NA), which specifically inhibit rapidly dividing cells, may face preexisting NA resistance or development of resistant cancer cells resulting in poor clinical prognosis. Treatment of cancers with oncolytic herpes simplex viruses (HSV) may face preexisting resistance or development of resistant cancer cells resulting in poor clinical prognosis. The invention overcomes chemotherapy resistance or resistance to oncolytic HSV by providing methods for detecting the resistance in a cancer disease based on the expression of SAM domain and HD domain-containing protein 1 (SAMHD1) in cancer cells. Furthermore provided are treatment options addressing the chemotherapy resistance such as a combination of a SAMHD1 inhibitor with a NA. Moreover, provided are treatment options addressing the resistance to oncolytic HSV such as a combination of a SAMHD1 inhibitor or depletion of SAMHD1 with an oncolytic HSV. The combination in some embodiments may furthermore include an inhibitor of CTP-synthetase. The invention provides new medicines and companion diagnostics supporting clinical treatment decisions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11352623-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021022105-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11193123-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021188840-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110632317-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11649442-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11649443-B2 |
| priorityDate |
2015-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |