| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca78d67211800a1ec7d7450b5d327ddb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1095169ee6a0932a6c89c8de154a33eb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-695 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-695
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-245 |
| filingDate |
2015-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06d84a2357559b05cee6c05662c2c0d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e5d8b56732b50ad23316e6de3e67e4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_351a8e235e0b8aae2f86c249a56ac60a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e87d551011f0041bc64ad54fdf32cd1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4271e5399ef6338e7827ec7641026e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd88b142702f6421cc33b7abefea7838 |
| publicationDate |
2018-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018311201-A1 |
| titleOfInvention |
Oral pharmaceutical composition comprising otilonium bromide and simethicone with certain bulk density and improved dissolution characteristics |
| abstract |
The present invention relates to a pharmaceutical composition for oral use comprising therapeutically effective amount of otilonium bromide in combination with therapeutically effective amount of simethicone, wherein the composition possesses certain bulk density and improved dissolution characteristics. Wherein a final blend prior to compression has a bulk density of at least 0.35 g/mL, and at least 85% of the otilonium bromide is released in 15 minutes in each of 0.1 N HCl, pH 4.5 and pH 6.8 buffer solutions at 37±0.5° C. using USP type II (paddle) apparatus rotating at 50 rpm. |
| priorityDate |
2015-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |