abstract |
The present invention relates to new solid phase peptide methods for synthesizing analogues that exhibit oxytocin antagonist activity, specifically Barusiban and its intermediates. Specifically, the present invention relates to a solid phase process for preparing a compound having the formula c[AA 1 -AA 6 ]-AA 7 -ol, wherein AA 1 is propionic acid, AA 2 is preferably D-Trp, AA 3 is Ile, AA 4 is preferably AlloIle, AA 5 is Asn, AA 6 is hCy, and AA 7 is preferably N-Me-Orn-ol, or a pharmaceutically acceptable salt or solvate thereof. |