http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018265548-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17832f1285ef628523e702754592582a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2016-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47fd060770dd252ff4ebf1b127c93a63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c92d49cd275d387dd184baae98b05b9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8117496e93a8087e9517f79e9a5b0546 |
| publicationDate | 2018-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018265548-A1 |
| titleOfInvention | LIGANDS FOR INTEGRIN AVß6, SYNTHESIS AND USES THEREOF |
| abstract | Disclosed are compound exhibiting highly active and selective binding to ανβ6 integrin, which are represented by the following general formula (I): Cyclo-(Arg-X 1 -Asp-X 2 -X 3 -X 4 -X 5 -X 6 -X 7 ) (I) wherein the variables groups X to X have the following meanings X 1 : Ser, Gly, Thr, X 2 : Leu, Ile, Nle, Val, Phe, X 3 : Gly, Ala, X 4 : Leu, He, Nle, Val, Phe, Lys, Tyr, Trp, Arg, X 5 : D-Pro, N-Me-D-lipophilic amino acids, X 6 : Pro, N-Me-amino acids, N-Me-Lys, N-Me-Lys(Ac), and X 7 ; Ala, Leu, He, Nle, Val, Phe, Tyr, Trp or wherein the sub-sequence -X 5 -X 6 - represents a β-turn mimetic differing from the meanings above, or pharmaceutically acceptable salts, esters, solvates, polymorphs or modified forms thereof represented by the following general formula (II): (X 0 ) n1 L(X 8 ) n2 wherein X 0 represents the compound of the general formula (I) as specified above (excluding one hydrogen atom to allow bonding to the linker), L represents a linker, X 8 represents the effector moiety and wherein n1 and n2 are each independently selected from the range of 1 to 5, wherein n1+n2 represents the number of valencies of the linker and is preferably in the range of from 2 to 6, more preferably 3-5, with the proviso that each of n1 and n2 is at least 1, as well as uses therefore in therapy and imaging. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022221144-A1 |
| priorityDate | 2015-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 318.