| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2876523df340f4a499e22ffcb5b3dfcb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate |
2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0490bc6a42beae38725782ad10aa7368
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_940f9bb9b89d3acebc3f02a2b5e532c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0ccef8443d7a0c4344ea0e62d53e223
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51813b303895f8c4db4ca8b8d44e2175 |
| publicationDate |
2018-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018251492-A1 |
| titleOfInvention |
Anti-endotoxin polypeptide |
| abstract |
An anti-endotoxin polypeptide is provided. The anti-endotoxin polypeptide having the formula (I) A 1 -L-C 1 , wherein A 1 and C 1 independently is a short peptide with α-helix, L is AGP (Ala-Gly-Pro) or a peptide bond, and the hydrophobicity of the hydrophobic terminus in the anti-endotoxin polypeptide is between about 0.425 and 0.765. The anti-endotoxin polypeptide of the invention can neutralize the lipopolysaccharide and has the low hemolysis and high salt resistance, simultaneously. The present invention also provides a method for design an anti-endotoxin polypeptide, the anti-endotoxic activity is adjusted through increasing and/or decreasing hydrophobicity of the hydrophobic terminal end. |
| priorityDate |
2017-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |