| abstract |
Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: n n n n n n n n n n where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity. |