http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018245044-A1

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filingDate 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5b81a4f3b67668dcffa9f5297c645fa
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publicationDate 2018-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2018245044-A1
titleOfInvention Method for natural killer cell expansion
abstract The present invention provides a method for in-vitro culturing and expanding natural killer (NK) cells in a cell culture medium comprising a population of NK cells, the method comprising a) adding an effective concentration of interleukin-21 (IL-21) at the beginning of the culturing process to said medium, b) adding repeatedly an effective concentration of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) to said medium, and c) adding repeatedly feeder cells or membrane particles thereof to said medium, wherein said feeder cells are B cell derived which are EBV immortalized; and wherein said expansion of NK cells in said cell culture medium is maintained for at least 3 weeks.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021108389-A1
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