http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018231524-A1

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filingDate 2018-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a3ab5397f3a112cf6da3f2693db5f2a
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publicationDate 2018-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2018231524-A1
titleOfInvention In vitro methods of identifying modulators of neuromuscular junction activity
abstract The present invention relates to an in vitro human neuromuscular junction model prepared from a co-culture of human pluripotent stem cell (PSC)-derived spinal motorneurons and human myoblast-derived skeletal muscle cells. The present invention also provides for methods of screening compounds for their ability to modulate neuromuscular junction activity by determining whether a candidate compound increases or decreases the activity of the in vitro human neuromuscular junction model.
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