| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_087bed7abab91ae0f927879f9fe8b273 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2001-364
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2001-302 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-36 |
| filingDate |
2018-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d59771e24f6b43caaffb05b07987634
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60ffd64665594794fdd0ec33eea94304
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2ef877cc8b49c14e9ba61aff5d83e17 |
| publicationDate |
2018-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018202904-A1 |
| titleOfInvention |
Methods and Devices for Soft and Osseous Tissue Clearing and Fluorescent Imaging |
| abstract |
Described herein is a bone tissue clearing method with enhanced optical access. Compositions and techniques for bone tissue clearing include continuous convective flow during the clearing process, amino alcohol to minimize tissue autofluorescence, and an imaging procedure that minimizes refractive index variations in light-sheet microscopy. These improvements allowed the Inventors to achieve whole-bone clearing with an imaging depth of up to about 1.5 mm while maintaining fluorescence and a signal-to-noise ratio (SNR) that permits detection and 3D placement of single cells. In various embodiments, the present application teaches methods and kits for clearing and optionally subsequently visualizing tissue containing bone. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023102718-A1 |
| priorityDate |
2017-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |