| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 |
| filingDate |
2016-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9900f69195318e82d41427d7fb4afc92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45afa5bf13e5b8c49c6b5b1677907b11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f33115cc9abfe3b6b76b0d3a2d2b323d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efafa380dfa3d0e0b37b450268405240
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54e30f7a9e8bc54232ed990f870a669c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adc2a9fef889b9adccb699bee7c450c4 |
| publicationDate |
2018-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018170912-A1 |
| titleOfInvention |
Salicylate inhibitors of melk and methods of use |
| abstract |
Provided herein are small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK) having the structure of formula (I), n n n n n n n n n n wherein X and R 1 -R 3 are defined in the specification. The compounds are useful for treating cancer and other conditions or diseases associated with aberrant MELK expression. Also provided herein are pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The invention also provides methods of treating cancers associated with over-expression of MELK. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10875844-B2 |
| priorityDate |
2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |