http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018162855-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f2e8d4f980eac450fe75cee98ac0758 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2016-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6de90d737ed4a7b5503565b8d183f27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55ba9d4168f1e96534661067b2c0c771 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47170694c263192950806920b4ef4e7d |
| publicationDate | 2018-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018162855-A1 |
| titleOfInvention | Pdd and bpd compounds |
| abstract | The invention relates to pyrridinobenzodiazepines (PDDs) comprising three fused 6-7-6-membered rings and to benzopyrridodiazecines (BPDs) comprising three fused 6-8-6-membered rings and, in particular, to PDD or BPD dimers linked together or PDD and BPD monomers linked to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, such as anti-proliferative agents. PDDs and BPDs may be represented by formula (I): and salts or solvates thereof, wherein R 2 , R 4 -R 6 and R 8 are independently selected substituent groups; and either: (i) R 9 and R 10 together form a double bond; (ii) R 9 is H and R 10 is OH; or (iii) R 9 is H and R 10 is OR A and R A is C 1-6 alkyl; wherein each of m, n, u and w may be 0 or 1; where (a) the compound is a dimer with each monomer being the same or different and being of formula (I) where one of R 1 , R 2 , R 3 and R 7 of the first monomer and one of R′ 1 , R′ 2 , R 3 and R′ 7 of the second monomer form together a bridge having the formula —X-L-X′— linking the monomers and m+n+u+w=1; or (b) a dimer and one of R 1 , R 2 and R 3 of the first monomer and one of R′ 1 , R′ 2 and R 3 of the second monomer form together a bridge having the formula —X-L-X′— linking the monomers and m=n=u=w=0; or (c) one of R 1 , R 2 , R 3 and R 7 has the formula: —X-L-X′-D or —(CH 2 )f-O—R 14 and m+n+u+w=0 or 1; or (d) R 7 has the formula: —X-L-X′— D or —(CH 2 ) g —O— 15 and m+n+u+w=1; and X-L-X′— is a linker group and D has the formula (II) or (III): |
| priorityDate | 2015-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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