| abstract |
This present disclosure is directed to compounds of formula (I): n n n n n n n n n n n n where R 1a , R 1b , R 1c , R 1d , R 1e , R 3 , R 4a , R 4b , R 4c , R 4d , R 6 , R 7 , and R 8 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A 4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions including the compounds described herein and methods of preparing the compounds described herein are also provided. |