http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018155686-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c16631f41ea72b000876633b74ad593 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-727 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0631 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9db011284a411173aae6ce6d01c074e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5907d680b12c8dc156e3341d90c89f2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcae92036b7cf3c22fae831679f5d8ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f65b43b7114b4573c63f4a272c24a38 |
| publicationDate | 2018-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018155686-A1 |
| titleOfInvention | Means and methods for generation of breast stem cells |
| abstract | The present invention is in the field of stem cell biology, in particular in the field of developmental and regenerative biology. The invention generally relates to a method of generating cells capable of differentiating to a multicellular organoid unit that morphologically and/or functionally resembles the terminal ductal-lobular unit. More precisely, said cells are generated by dissociating mammary epithelial tissue, thereby gaining cells and culturing said cells in presence of a compound which elevates cAMP levels in a collagen gel. Under said culturing conditions said cells form a multicellular organoid unit facilitating to obtain a breast stem cell by isolating a single cell from said multicellular organoid unit. The present invention also relates to enriching said cells and differentiating them to a multicellular organoid that morphologically and/or functionally resembles the terminal ductal-lobular unit and use of said cells or said multicellular organoid in testing a compound. Furthermore, the present invention relates to a composition comprising said breast stem cells or the multicellular organoid. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021145467-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023025928-A1 |
| priorityDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 653.