http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018133329-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8271994153280f878a8728bd9ec8c9f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f3cb5ba249ba2cfcd669097da1c3fb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_186183989085d2f08e0f69156e57f174 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate | 2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5456795267cad8c476f80bef52c9b6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77d42b44d64c96de4a8e6491fe73e03f |
| publicationDate | 2018-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018133329-A1 |
| titleOfInvention | Compositions and method for stabilizing a pharmaceutical formulation, and methods of making and using the same |
| abstract | The disclosure pertains to compositions to stabilize nutrient, food, pharmaceutical, and biological formulations by preventing the crystallization or precipitation of carbohydrates used in the formulations. The compositions contain (i) one or more carbohydrates, sugars, sugar alcohols, analogs thereof, and/or derivatives thereof and (ii) one or more antifreeze proteins (AFPs), mimetics thereof, and/or analogs thereof and methods of making and using the same. The AFP may be selected from antifreeze polypeptides and antifreeze peptides, analogs and mimetics of antifreeze proteins, active fragments of such antifreeze proteins, polypeptide and peptide mimetics, antifreeze peptoids and polymers, and combinations thereof. The carbohydrate, sugar or sugar alcohol has the formula C m H n O p , where m is an integer of 5 or 6, n is an integer of 2m or 2m+2, and p is equal to m, or the formula C a H b O c , where a is an integer of 10-12 or 15-18, b is 2a−2 when a is an integer of 10-12 or 2a−4 when a is an integer of 15-18, and c is a−1 when a is an integer of 10-12 or a−2 when a is an integer of 15-18. The AFP, AFP analog, or AFP mimetic inhibits or controls crystallization of the carbohydrate (e.g., during the storage of the solution of the carbohydrate or the analog or derivative thereof, during the freeze-drying of a formulation using the carbohydrate or the analog thereof) and stabilize the solution or the formulation using the carbohydrate or the carbohydrate analog or derivative. |
| priorityDate | 2016-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.