Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fe70490047125a7f0ada8d0785c405d |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14133 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14171 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
filingDate |
2017-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb7d7dd45a4ac92334364bdeb7b77c77 |
publicationDate |
2018-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2018127471-A1 |
titleOfInvention |
Modified aav capsids and uses thereof |
abstract |
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein that binds heparan sulfate proteoglycans, where the AAV virions exhibit greater infectivity of retinal cells, altered tropism and/or the ability to bind and cross the inner limiting membrane following intravitreal injection. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11427931-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11352644-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020223231-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11021519-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11510950-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773406-B2 |
priorityDate |
2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |