abstract |
The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX 2 X 3 X 4 AX 6 X 7 EIRWLPNL X 16 X 17 X 18 QRX 21 AFIX 25 X 26 LX 28 X 29 . The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent. |