http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018118778-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate | 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21cffd131cabd721aaee1922c59940b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a745d48feff509b659499cf627b8af5 |
| publicationDate | 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018118778-A1 |
| titleOfInvention | Cortistatin analogues and syntheses and uses thereof |
| abstract | Compounds of Formula (A′), (B′), (C′), (D′), (E′), (A″), (B″), (C″), (D″), (E″), (G1), and (G2) are useful as therapeutics for treating a wide variety of conditions in a host such as a human, e.g., including but not limited to, conditions associated with angiogenesis and/or which are mediated by CDK8 and/or CDK19 kinase activity. Also provided are methods of modulating the β-catenin pathway, methods of modulating STAT1 activity, methods of modulating the TGFβ/BMP pathway, methods of modulating HIF-1-alpha activity in a cell, and methods of increasing BIM expression to induce apoptosis, using an effective amount of a compound of Formula (A′), (B′), (C′), (D′), (E′), (A″), (B″), (C″), (D″), (E″), (G1), or (G2). |
| priorityDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 995.