| abstract |
A directly compressed extended release cyclobenzaprine tablet and method for making the tablet that includes homogenously mixing: (i) cyclobenzaprine, (ii) a filler selected from the group consisting of lactose, spray-dried lactose, mannitol, and combinations thereof; and (iii) a glidant selected from the group consisting of silica, peptized silica, and combinations thereof; and (iv) hydroxypropyl methylcellulose (HPMC) to provide a first mixture; homogenously mixing a lubricant with the first mixture to provide a second mixture; and directly compressing the second mixture into a tablet, having a ratio of filler to matrix forming polymer ranges from 1.66 to 2.07. |