| abstract |
A compound of the general formula (I) wherein Y represents —CH 2 — or >C=0; R 1 is selected from the group consisting of A1, A2 and A3; R 2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4; R 3 is selected from the group consisting of H, halogen, and C1-C4 alkyl; R 4 is selected from the group consisting of C1-C4 alkyl, C3-C4-cycloalkyl, C1-C4 alkyl substituted with C1-C4 alkoxy, and CHF 2 , and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer. |