abstract |
Beta-hairpin peptidomimetics of the general formula (I), cyclo[P 1 —P 2 —P 3 —P 4 —P 5 —P 6 —P 7 —P 8 —P 9 —P 10 —P 11 —P 12 -T 1 -T 2 ],and pharmaceutically acceptable salts thereof, with P 1 to P 12 , T 1 and T 2 being elements as defined in the description and the claims, have broad spectrum Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. n They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. n These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. |