| abstract |
This disclosure relates to compositions and methods for the treatment of dermal and epidermal wounds. In particular, the disclosure relates to treating dermal and epidermal wounds based on application of a composition comprising an opioid receptor antagonist, a pharmaceutically acceptable carrier, and an enkephalinase. In some cases, the enkephalinase comprises aminopeptidase N (APN), neprilysin, dipeptidyl peptidase 3 (DPP3), carboxypeptidase A6 (CPA6), leucyl/cystinyl aminopeptidase (LNPEP), angiotensin-converting enzyme (ACE), endothelin-converting enzyme-2 (ECE-2), a peroxin (PEX), damage induced neuronal endopeptidase (DINE), Kell protein, or a combination thereof. |