http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018022735-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a695659dff59e19b48ff41f2a54442dc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 |
| filingDate | 2016-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21ce0a502bda3c402cba257180992b48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a03faa9af9ecf41d17cb9173ad7d740 |
| publicationDate | 2018-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018022735-A1 |
| titleOfInvention | Modulators of the p70s6 kinase for use in the treatment of brain disorders and triple-negative breast cancer |
| abstract | The invention provides compounds for use in the treatment of a disease or condition selected from brain disorders and triple-negative breast cancer, the compounds being of the formula (1): n n n n n n n n n n or a salt or tautomer thereof; n wherein:n X 1 is N or N + (O − ); X 2 is N or CH; Q is selected from a C1-3 alkylene group, cyclopropane-1,1-diyl and cyclobutane-1,1-diyl; R 1 is selected from hydrogen and C 1-4 alkyl; R 2 , R 3 and R 4 are the same or different and each is selected from hydrogen and fluorine; Ar 1 is a benzene, thiophene, naphthyl or pyridine ring optionally substituted with 1, 2 or 3 substituents selected from fluorine; chlorine; bromine; C 1-4 hydrocarbyl; C 1-4 hydrocarbyloxy; trifluoromethyl; difluoromethyl; cyano; trifluoromethoxy; difluoromethoxy; Ar 2 is a monocyclic 5- or 6-membered heteroaryl ring containing 1, 2 or 3 heteroatom ring members selected from O, N and S and being optionally substituted with 1, 2 or 3 substituents selected from fluorine; C 1-4 hydrocarbyl; amino; mono-C 1-4 hydrocarbylamino and di-C 1-4 hydrocarbylamino; and wherein, in each substituent consisting of or containing C 1-4 hydrocarbyl, the C 1-4 hydrocarbyl is selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, cyclopropyl, cyclobutyl and cyclopropylmethyl. |
| priorityDate | 2015-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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