| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_151b07306133dc83b4b5101e2318081d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01153
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2015-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e11b79690f427652de73cc99a26c871c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7f512d9b726f6de63478cbf85fd2bf1 |
| publicationDate |
2018-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018016640-A1 |
| titleOfInvention |
Pik3ca novel mutations detection for diagnosis of acquired cetuximab resistance in metastatic colorectal cancer patients |
| abstract |
Disclosed is a kit for detecting drug resistance of cetuximab in the treatment of metastatic colorectal cancer. The kit comprises a substance used for detecting gene mutations in Exon 19 of the PIK3CA gene, and may further comprise a specification recording the following contents: if Exon 19 in the PIK3CA gene of a patient with metastatic colorectal cancer as a subject to be tested, who is intended to receive cetuximab treatment or is receiving cetuximab treatment and does not have drug resistance, has at least one of K944N, F930S, V955G, V955I, and K966E mutations, the subject to be tested will develop drug resistance or will be a candidate to develop drug resistance when receiving or continuing to receive cetuximab for treating metastatic colorectal cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773440-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286531-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11525163-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180803-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11453913-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459611-B2 |
| priorityDate |
2014-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |