| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56dd81585a77aa52c8b63b982f58a9d7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4716
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5438
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-021 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 |
| filingDate |
2017-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_335c38b5659786c795a5320f4324e633
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9de67140a9d505b11698e17e86643a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3244615c85d37ba1a88a621085e2b87e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3be912a8b3e8f66ce7d115319d9f488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c8146c71457f5cbf5d26f667ef35c93 |
| publicationDate |
2017-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017370907-A1 |
| titleOfInvention |
Dynamic monitoring of receptor tyrosine kinase (rtk) activity and pathways in living cells using real-time microelectronic cell sensing technology |
| abstract |
A method of identifying a potential therapeutic compound that affects a Receptor Tyrosine Kinase (RTK) pathway in cancer cells, which includes: providing a device capable of measuring cell-substrate impedance; culturing cancer cells in serum-free media in at least two wells of the device; adding to a first well a proposed therapeutic compound that affects a RTK pathway and a RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells and optionally determining cell indices from the monitored cell-substrate impedance; and determining a difference in impedance or optionally cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10551371-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10539523-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10690677-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11360072-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11604197-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10533985-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10067121-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-D941488-S
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10725023-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11746328-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10620188-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11346797-B2 |
| priorityDate |
2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |