| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a420afdd82fa01687e8221e7d96def3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-44 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0238
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J23-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J35-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J35-0013 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-28 |
| filingDate |
2015-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4838a7923f30028a0c6b9188a7fa7783
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b3978ab856b9a5057c913291d5f0cee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9220e351e9e2452c96b32d0f851b6478 |
| publicationDate |
2017-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017362162-A1 |
| titleOfInvention |
Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis |
| abstract |
A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones. |
| priorityDate |
2014-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |