Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2015-8518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6489 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate |
2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_002a39fc88e47fdb3330af4094f5b722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09d3eda9364e7e3f8a070d5df5c1da95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8d1cd98c9443bef55857b995fdc4e67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_973ff7ce33b9c5f730a90445e1a94cfb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8dfd4fd1f80b9a06d842af2667a6c03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b0e65f6722dab22c8233aa56f25f2bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4385402d180846fb83ee63cc98442627 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_052c655dd3bbe74281decd92a1900b45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67a66ce1070e2a633b11c1be258882fa |
publicationDate |
2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2017332610-A1 |
titleOfInvention |
Methods for breaking immunological tolerance using multiple guide rnas |
abstract |
Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11697828-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112639121-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10457960-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021113297-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021011493-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773176-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11618893-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020208177-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11576984-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019173615-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019190990-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019190922-A1 |
priorityDate |
2016-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |