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publicationDate 2017-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2017298411-A1
titleOfInvention System and method for detecting of alpha-methylacyl-coa racemase (amacr) and prostate cancer
abstract A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H 2 O 2 upon combination with AMACR in the bodily sample and a biosensor for determining a level of generated H 2 O 2 . The reaction solution includes a (2R)-2-methylacyl-CoA epimer that can be chirally inverted by AMACR to a (2S)-2-methylacyl-CoA epimer and an enzyme that carries out beta oxidation with the (2S)-2-methylacyl-CoA epimer to generate hydrogen peroxide (H 2 O 2 ).
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