| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d77625451c3066a1c9a475578e417bc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2869 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-26 |
| filingDate |
2017-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_459d4d51e2cdb2109b9d384d5093eb50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cc12f0ec40dbd7de17a49e7d5b691f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_debc5d4163db05741f74fcd9b371e225
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6291331c0796de83e73f412666b864f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_262f8bf353687f4334f8c0bc2662ee18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f767e0e173f2e388f0d19bcdf8f8979
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2dfc02b9c945268aad2701385fb999b |
| publicationDate |
2017-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017267770-A1 |
| titleOfInvention |
Methods for Detecting 1,25-Dihydroxyvitamin D and Related Antibodies |
| abstract |
There is disclosed an assay method for selectively detecting 1,25-dihydroxy-vitamin D in a biological fluid sample. According to the method, the pH of the test sample is adjusted to 6-9 and a receptor protein comprising the Ligand Binding Domain of Vitamin D Receptor (VDR-LBD) is added to the test sample, thereby obtaining the formation of a VDR-LBD/1,25-dihydroxyvitamin D complex in which the VDR-LBD portion is conformationally changed with respect to unbound VDR-LBD. The VDR-LBD/1,25-dihydroxyvitamin D complex is then detected by means of a capture moiety which is capable of specifically binding to VDR-LBD bound to 1,25-dihydroxyvitamin D. Also disclosed are an assay kit and an antibody for carrying out the method. The assay is preferably a sandwich immunoassay. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11261257-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10501548-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10983136-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017322230-A1 |
| priorityDate |
2013-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |