| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fa9993bc2e6a032b3d8731b4c4e12a6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-575 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-646
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48261
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-4833
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-385 |
| filingDate |
2015-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d87c93a5638904291ea5b25f97ff91e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a9b315a0bb7ad5d93890276288d1a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c98b2855cc4d7f12c4b93b778ee1fee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e73e8a5f27597e45f86d988700a0796
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c83bb331685beeb57ebd11c084c9a187 |
| publicationDate |
2017-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017246313-A1 |
| titleOfInvention |
An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof |
| abstract |
The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours. The said oligosaccharide-protein conjugates are useful in production of monovalent vaccine or multivalent combination vaccines and as diagnostic tool. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11376323-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10729763-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10688170-B2 |
| priorityDate |
2014-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |