Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c731b1258bdc5ec03140bf17ca27dc40 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96433 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
2015-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7748b367efd48f3ec68884fdd9e6d358 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b89bfcfb39fd328aec3341e13a84c78 |
publicationDate |
2017-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2017241986-A1 |
titleOfInvention |
Methods for identifying compounds that alter the activity of irhom polypeptides and use thereof |
abstract |
Methods for identifying a compound that modulates activity of an iRhom polypeptide according to aspects of the present invention are described herein which include contacting a cell expressing an iRhom polypeptide with a test compound; and determining the effect of the compound on activity of the iRhom polypeptide. Detection of a decrease in proteolytic activity of the iRhom polypeptide indicates that the compound is capable of one or more of: reducing tumor growth, reducing tumor progression, treatment of cancer and promoting hair growth in a subject, and detecting an increase in proteolytic activity of the iRhom polypeptide indicates that the compound is capable of accelerating wound healing in a subject. |
priorityDate |
2014-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |