abstract |
A compound of formula (I): for use in the prevention or treatment of a bacterial infection wherein: A is either S or Se; RA is selected from: wherein: each of Y 1 , Y 2 , Y 3 , Y 4 and Y 9 is independently selected from CH or N, wherein at least three of Y 1 , Y 2 , Y 3 , Y 4 and Y 9 is CH; V is selected from O, CH—OR 01 , N—CO 2 —R C2 or N—R N2 ; one of Y 5 , Y 6 , Y 7 and Y 8 is selected from CH and N, and the others are CH; X is selected from NH, S or O; R C1 is selected from O—R O2 or NHR N1 ; R O1 is selected from H and C 1-3 unbranched alkyl; R O2 is C 1-3 unbranched alkyl; R N1 is selected from H and C 1-3 unbranched alkyl; R N2 is C 1-3 unbranched alkyl; R C2 is either C 1-3 unbranched alkyl or C 3-4 branched alkyl; R C3 is selected from C 1-3 unbranched alkyl and C 2 H 4 CO 2 H; R C4 is either H or Me; R C5 is either H or Me; R C6 represents one or two optional methyl substituents; and n is an integer from 2 to 8. |