http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017220710-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e5af0488430402a9047e5bac8a5332a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_433a167c20f7e5e6e9e0bf7a6b28f895 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F17-5009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F19-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4bdec337081cfe85cf0dad9c15cd48f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ab65ecce55107369cf23ab71928ccc2 |
| publicationDate | 2017-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2017220710-A1 |
| titleOfInvention | Quantitative methods for heterogeneous sample composition determination and biochemical characterization |
| abstract | Methods involving the use of mathematical models of competitive ligand-receptor binding to characterize mixtures of ligands in terms of compositions and properties of the component ligands have been developed. The associated mathematical equations explicitly relate component ligand physical-chemical properties and mole fractions to measurable properties of the mixture including steady state binding activity, 1/K d,apparent or equivalently 1/EC50, and kinetic rate constants k on,apparent and k off,apparent allowing; 1) component ligand physical property determination and 2) mixture property predictions. Additionally, mathematical equations accounting for combinatorial considerations associated with ligand assembly are used to compute ligand mole fractions. The utility of the methods developed is demonstrated using published experimental ligand-receptor binding data obtained from mixtures of afucosylated antibodies that bind FcγRIIIa (CD16a) to: 1) extract component ligand physical property information that has hitherto evaded researchers 2) predict experimental observations and 3) provide explanations for unresolved experimental observations. |
| priorityDate | 2015-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.