| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_acae886d7fc13db991247cb273eb71bd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70596
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57438
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2015-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55a07c7aa4d74810401850ca994926f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_097d1f2fdef414916963994119f76e90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_320b2fe654fcdfb8a3f04019eaa81dca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1601a6e26b0e51f23f6267b12d1db6b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0098d7d18a56c9a30b655dc78ec9da7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6436e9b201fce41744c1e645e831f6df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_016583c0387888ee64927405531a4d2e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_582504878840c524c19e961c86d5d036 |
| publicationDate |
2017-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017219590-A1 |
| titleOfInvention |
Hepatocellular carcinoma marker |
| abstract |
The problem addressed by the present invention is to provide a marker for detecting hepatocellular carcinoma, wherein the hepatocellular carcinoma marker comprises a glycoprotein that first becomes present in the liver with the occurrence of cancer, without depending on changes in the state of the liver. The present invention provides a hepatocellular carcinoma marker comprising an NPA lectin-binding glycoprotein having an NPA lectin-binding glycan epitope that has at least one of the following properties (1) to (5): (1) the glycan epitope does not include core fucose (fucose α1→6 glycan); (2) the glycan epitope comprises a complex-type glycan having three (four or fewer) mannoses; (3) the glycan epitope does not include a high-mannose-type glycan having five or more mannoses; (4) the glycan epitope comprises a complex-type glycan that does not depend on the property of binding to LCA lectin; and (5) the glycan epitope comprises a complex-type glycan that does not depend on the property of binding to ConA lectin. By detecting the hepatocellular carcinoma marker of the present invention in a test sample, it is possible to determine the presence of hepatocellular carcinoma or the level of progression or malignancy of carcinoma. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11046778-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110763849-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11467162-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022171777-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113480629-A |
| priorityDate |
2014-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |