http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017212982-A1

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publicationDate 2017-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2017212982-A1
titleOfInvention Thermostabilized mutant-predicting apparatus for membrane protein, a thermostabilized mutant-predicting method, and computer program product
abstract The present disclosure includes predicting a three-dimensional structure of one residue mutant of a membrane protein where respective amino acid residues have been substituted by all amino acids, calculating a solvation entropy change in formation of a tertiary structure from a primary structure or formation of the tertiary structure from secondary-structure units within a transmembrane segment, and extracting a candidate of an amino acid mutant to be thermostabilized based on a difference between a solvation entropy change in the membrane protein and a solvation entropy change in the amino acid mutant.
priorityDate 2014-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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