| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5ad8562c578b061df7a2c3aee9d0e24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5d9a157665564d9a16b3270441114c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2393832434a0bfa947ad8429d689cc4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-08 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0618
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M35-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0793
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0797
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-079
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00 |
| filingDate |
2016-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29fb5c74b64997b1138d164d08285bbf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb9d24b544b3493807d3424e704902e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee577e36a1643c67130f21d8a39a1c32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0238c6cd38978c2ef890caf99d9f3cdc |
| publicationDate |
2017-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017211029-A1 |
| titleOfInvention |
Neurovascular unit(nvu)-on-a-chip and method of fabricating the same |
| abstract |
Provided are a neurovascular unit (NVU)-on-a-chip and a method of fabricating the same, which 3-dimensionally integrates various human brain cells in a microfluidic platform by using a brain cell co-culture technique so as to simulate a similar environment to the human brain in vitro. The NVU-on-a-chip includes an extracellular matrix (ECM) simulation material ( 70 ) in a gel state; and at least one channel ( 75 ) which passes through the ECM simulation material ( 70 ) and perfuses a culture medium, in which the ECM simulation material ( 70 ) contains a plurality of types of human brain cells on an outer side of the channel ( 75 ), a brain microvessel endothelial cell lining ( 91 ) is formed on an inner side of the channel ( 75 ), and the plurality of types of human brain cells and the brain microvessel endothelial cell lining ( 91 ) contact each other through the channel ( 75 ) to simulate a blood brain barrier (BBB) of a human brain and a neurovascular unit (NVU) of the human brain including the BBB. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112410220-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111575183-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113186162-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022062895-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020113837-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3950923-A4 |
| priorityDate |
2016-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |