Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0693ed4f2b7b1fab97515ac2f1f311c |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-09 |
filingDate |
2017-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ac4460e9651a0052a8fc513abffff5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfcc7a4a953f84d8e481031a31bea815 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58de3ab7f17d46d3a6479e63830e1399 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_411439bf157e8c33e815cbc2e4918343 |
publicationDate |
2017-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2017209388-A1 |
titleOfInvention |
Reconstituted apolipoprotein b lipoparticle, a preparation method and uses thereof |
abstract |
The present invention provides a method for preparing a reconstituted apolipoprotein B lipoparticle and the method comprises steps of (a) dissolving an apolipoprotein B and a lipid in a first buffer containing 2 M to 8 M urea and 1 wt % to 15 wt % amphiphilic compounds to form a mixture; and (b) dialyzing the mixture against a second buffer containing 0 M to 2M urea and 0 wt % to 0.5 wt % amphiphilic compounds for 1 to several times for lowering concentrations of the urea and the amphiphilic compounds in the mixture. The present invention further provides an apolipoprotein B lipoparticle and a use for the production of an apolipoprotein B lipoparticle used for delivering a hydrophobic substance. |
priorityDate |
2013-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |