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filingDate 2015-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2017183616-A1
titleOfInvention Systems and methods for biomimetic fluid processing
abstract Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels.
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